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Chemistry of Phenethylamines Related to Mescaline

Alexander T. Shulgin

Journal of Psychedelic Drugs January 1, 1979 DOI: 10.1080/02791072.1979.10472091 via OpenAlex

Summary

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This paper reviews the chemistry of phenethylamines structurally related to mescaline, a naturally occurring psychedelic alkaloid. It describes the chemical synthesis, structural variations, and analytical methods such as chromatography used to identify and characterize these compounds. The review covers how modifications to the phenethylamine backbone affect pharmacological activity and discusses the relationship between chemical structure and psychedelic potency. The authors provide a systematic overview of known synthetic routes and analytical techniques relevant to studying mescaline analogs.

Study at a glance

Characteristics Review Peer reviewed
Topics Mescaline
Keywords Phenethylamines Chemistry
Citations 20
Key finding Structural modifications to the phenethylamine backbone of mescaline alter psychedelic potency, and these analogs can be synthesized and characterized using established chemical and chromatographic methods.

Abstract

(1979). Chemistry of Phenethylamines Related to Mescaline. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 41-52.

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