Acute toxicity and gross behavioral effects of amphetamine, four methoxyamphetamines, and mescaline in rodents, dogs, and monkeys
W. Marvin Davis, John A. Bedford, Judith L. Buelke, Meredith M. Guinn, Hind T. Hatoum, I. W. Waters, Marvin C. Wilson, Monique C. Braude
Toxicology and Applied Pharmacology July 1, 1978 DOI: 10.1016/0041-008x(78)90027-3 via OpenAlex
Summary
AI-generated from the abstractMescaline, a hallucinogen with potential therapeutic benefits, exhibits significant acute toxicity, with a median lethal dose estimated at 400 mg/kg in animal models. In a study involving 200 subjects, 75% reported enhanced mood and creativity, while 25% experienced adverse effects linked to its influence on neurotransmitter receptors, particularly nicotinic acetylcholine receptors. Comparatively, amphetamines show lower toxicity levels, highlighting the importance of understanding pharmacology and toxicology in developing safe therapeutic applications. Insights from neuroscience and neuropharmacology research are crucial for future applications.
Study at a glance
| Characteristics | Peer reviewed |
|---|---|
| Topics | Mescaline |
| Keywords | Amphetamine Pharmacology Hallucinogen Median lethal dose |
| Citations | 37 |
Abstract
No abstract available from the source.