Effects of Mescaline in Laboratory Animals and Influence of Ataraxics on Mescaline-Response
F. M. Sturtevant, Victor A. Drill
Experimental Biology and Medicine June 1, 1956 DOI: 10.3181/00379727-92-22485 via OpenAlex
Summary
AI-generated from the abstractMescaline injected into dogs and cats, including directly into the brain's lateral ventricle in cats, first caused acute autonomic effects and then catatonia. Pretreatment with the tranquilizing drugs chlorpromazine, reserpine, and azacyclonol appeared to alter or prevent these responses.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Dogs and cats |
| Interventions | Mescaline Chlorpromazine Reserpine Azacyclonol |
| Topics | Mescaline |
| Keywords | Cats Reserpine Chlorpromazine Catatonia |
| Citations | 15 |
| Key finding | Mescaline-induced acute autonomic effects and catatonia in dogs and cats appeared to be altered or prevented by pretreatment with chlorpromazine, reserpine, and azacyclonol. |
Abstract
Mescaline, injected intravenously and intraperitoneally into dogs and cats and into the lateral ventricle of the brain of cats, produced acute autonomic effects followed by catatonia. These responses appeared to be altered or prevented by pretreatment with the ataraxic agents chlorpromazine, reserpine, and azacyclonol.