A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE
British Journal of Pharmacology September 1, 1975 DOI: 10.1111/j.1476-5381.1975.tb07621.x via OpenAlex
Summary
AI-generated from the abstractIn male mice from seven genetically diverse laboratory strains, mescaline (35 mg/kg) inhibited emotional defecation and stimulated open field activity in five strains (A2G, C3H/He, C57BR/cd, CBA/Cam, F/St) but not in two others (ICFW, Schneider). The degree of emotional defecation under saline control correlated positively with mescaline's inhibitory effect. Pre-treatment with tranylcypromine did not alter emotional defecation or mescaline's inhibition of it.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Male mice from seven genetically diverse laboratory strains |
| Intervention | Tranylcypromine |
| Dose | 35 mg/kg body weight mescaline hemi-sulphate; 20 mg/kg body weight tranylcypromine |
| Topics | Mescaline |
| Keywords | Saline Open field Body weight Psychology |
| Citations | 13 |
| Key finding | Mescaline inhibited emotional defecation and stimulated open field activity in five of seven mouse strains, with a positive relationship between baseline emotional defecation and mescaline's inhibitory effect. |
Abstract
Mescaline hemi‐sulphate (35 mg/kg body weight) was injected intraperitoneally into male mice ( Mus musculus ) from seven genetically diverse laboratory strains. The effect of mescaline was found by comparison of the emotional defaecation and open field activity of mice after mescaline injection with the performance of the same mice after a subsequent saline (0.9% w/v NaCl solution) control injection. In strains A2G, C3H/He, C57BR/cd, CBA/Cam and F/St, mescaline inhibited emotional defaecation and stimulated open field activity. These effects did not occur in strains ICFW and Schneider. A positive relationship was found between the degree of emotional defaecation characteristic of each strain in the saline control experiment and the inhibitory effect of mescaline on emotional defaecation. Pre‐treatment of mice with tranylcypromine (20 mg/kg body weight, i.p.) had no effect on emotional defaecation or on its inhibition by mescaline.