Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice

In mice, the compound 5,6-dihydroxytryptamine (5,6-DHT) suppressed head-twitch responses caused by 5-HTP, 5-HT, mescaline, and fludiazepam. The effect varied by drug: 5,6-DHT strongly inhibited twitches from 5-HTP and 5-HT, moderately inhibited those from mescaline, and weakly inhibited those from fludiazepam. These results suggest that head twitches induced by these substances involve different serotonergic mechanisms.

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Abstract

Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsutaka Nakamura, Mitsutaka Nakamura Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Correspondence: Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideaki Fukushima Hideaki Fukushima Research and Development Centre, Pharmaceuticals Division, Sumitomo Chemical Co. Ltd., 4-2-1, Takatusukasa, Takarazuka, Hyogo, 665, Japan Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 30, Issue 1, September 1978, Pages 56–58, https://doi.org/10.1111/j.2042-7158.1978.tb13156.x Published: 12 April 2011 Article history Received: 01 August 1977 Published: 12 April 2011