Synergism of Amines and Antagonism of Reserpine to Morphine Analgesia
E. B. Sigg, G. Caprio, J. A. Schneider
Experimental Biology and Medicine January 1, 1958 DOI: 10.3181/00379727-97-23656 via OpenAlex
Summary
AI-generated from the abstractReserpine blocks the pain-relieving effects of morphine, meperidine, and codeine in mice. In contrast, several amines including 5-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline, and epinephrine lengthen and strengthen morphine's analgesic effect, while iproniazid and choline-p-tolyl-ether do not. The authors discuss possible mechanisms for these interactions, focusing on how amines enhance and reserpine opposes morphine analgesia.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Reserpine morphine meperidine codeine 5-hydroxytryptamine tryptamine amphetamine mescaline epinephrine iproniazid choline-p-tolyl-ether |
| Topics | Mescaline |
| Keywords | Reserpine Morphine Iproniazid Pharmacology Codeine |
| Citations | 78 |
| Key finding | Reserpine antagonizes morphine, meperidine, and codeine analgesia in mice, while several amines prolong and enhance morphine analgesia. |
Abstract
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryptamine, amphetamine, mescaline and epinephrine prolong and enhance morphine analgesia whereas iproniazid and choline-p-tolyl-ether fail to do so. (3) Possible mechanisms involved in the synergistic action of amines and the antagonistic action of reserpine on morphine analgesia are discussed.