Effect of zotepine on head-twitch induced by L-5-Hydroxytryptophan,mescaline and 2,5-Dimethoxy-4-methylamphetamine in mice and rats.
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki, Kyoichi Shimomura, Hisashi Satoh, Jo Mori
The Japanese Journal of Pharmacology January 1, 1983 DOI: 10.1254/jjp.33.319 via OpenAlex
Summary
AI-generated from the abstractZotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate zotepine has a potent anti-hallucinogenic effect.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Interventions | Zotepine haloperidol cyproheptadine |
| Topics | Mescaline Serotonin |
| Keywords | Cyproheptadine Haloperidol Pharmacology Hallucinogen |
| Citations | 9 |
| Key finding | Zotepine and haloperidol produce potent inhibitory effects on head-twitch induced by L-5HTP, mescaline, and DOM, indicating zotepine has a potent anti-hallucinogenic effect. |
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.