Cross tolerance to antinociception elicited by intracerebroventricular administration of mescaline and morphine to rabbits, and EEG correlates
Sergio Solbes Ferri, A. Santagostino, Pier Carlo Braga
Psychopharmacology January 1, 1976 DOI: 10.1007/bf00427611 via OpenAlex
Summary
AI-generated from the abstractRepeated administration of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) directly into the brain ventricles of rabbits produces tolerance and cross-tolerance to their pain-blocking effects. Electrical recordings from various brain regions show that partial tolerance also develops to the electroencephalographic changes caused by chronic mescaline treatment. Comparing certain effects of mescaline with those of morphine suggests that the two drugs share some common biochemical and neural mechanisms.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | morphine mescaline |
| Dose | 10 mug/kg morphine, 100 mug/kg mescaline |
| Topics | Mescaline |
| Keywords | Morphine Nociception Cross-tolerance Pharmacology |
| Citations | 4 |
| Key finding | Tolerance and cross-tolerance to the antinociceptive effect of equipotent doses of morphine and mescaline occur after repeated intracerebroventricular administration in rabbits, and partial tolerance develops to the EEG effects of mescaline. |
Abstract
Tolerance and cross tolerance to the antinociceptive effect of equipotent doses of morphine (10 mug/kg) and mescaline (100 mug/kg) are shown in the rabbit after their repeated intracerebroventricular administration. The recording of the electrical activity of different brain areas indicates that a partial tolerance also develops to the EEG effects in animals undergoing chronic treatment with mescaline. The comparison of certain of the mescaline-induced effects with those of morphine suggests that some biochemical and neural patterns are common to the 2 drugs.