6-Hydroxydopamine inhibits some effects of mescaline centrally administered to rabbits
Sergio Solbes Ferri, Roser Reina, C. Spadaro, P. C. Braga
Psychopharmacology June 1, 1977 DOI: 10.1007/bf01457850 via OpenAlex
Summary
AI-generated from the abstractIn rabbits, the narcotic antagonist naloxone does not block pain relief (antinociception) caused by 100 micrograms per kilogram of mescaline injected into the brain, but pretreatment with 6-hydroxydopamine (6-OHDA) does prevent this effect. 6-OHDA also prevents the stereotyped behavior that follows central mescaline administration. Because 6-OHDA destroys nerve terminals that contain catecholamines, the findings suggest that catecholamines play a crucial role in the effects produced by the hallucinogen mescaline when given centrally to rabbits.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rabbits |
| Interventions | Mescaline Naloxone 6-hydroxydopamine |
| Dose | 100 microgram/kg of mescaline |
| Topics | Mescaline |
| Keywords | Hydroxydopamine Pharmacology +-naloxone Antagonist |
| Citations | 3 |
| Key finding | 6-hydroxydopamine, but not naloxone, prevents mescaline-induced antinociception and stereotyped behavior in rabbits, suggesting a crucial role for catecholamines. |
Abstract
The narcotic antagonist naloxone does not antagonize antinociception elicited in the rabbit by 100 microgram/kg of mescaline centrally administered, whereas pretreatment with 6-hydroxydopamine (6-OHDA) inhibits this mescaline effect. Stereotyped behavior of rabbits following central mescaline administration is also prevented by 6-hda pretreatment. Since 6-OHDA in known to produce a degeneration of catecholamine containing nerve terminals, a crucial role of catecholamines is suggested in the complex of effects seen in the rabbit after central administration of the hallucinogen.