Angel Dust
JAMA August 8, 1977 DOI: 10.1001/jama.1977.03280060059027 via OpenAlex
Summary
AI-generated from the abstractPhencyclidine (PCP, Angel Dust) was developed as an anesthetic in the 1950s but caused prolonged postoperative agitation and delirium, preventing its human medical use. It is now used only as an animal anesthetic. A chemical relative, ketamine, is used for human anesthesia. On the street, PCP appears as powder, tablets, or capsules in various colors and is made by amateur chemists from easily obtained ingredients. Because it is simple to produce, PCP is often sold as a substitute for harder-to-find psychedelics like mescaline.
Study at a glance
| Characteristics | Historical analysis Peer reviewed |
|---|---|
| Topics | Ketamine Mescaline |
| Keywords | Phencyclidine Ketamine hydrochloride Medicine Anesthetic agent |
| Citations | 31 |
| Key finding | Phencyclidine was rejected for human anesthesia due to side effects like postoperative agitation and delirium but remains an animal anesthetic and is commonly sold on the street as a substitute for other psychedelic drugs. |
Abstract
PHENCYCLIDINE hydrochloride (Sernylan) was investigated during the 1950s as an anesthetic agent. Although it was found to be effective for analgesia and anesthesia, certain side effects, especially postoperative agitation and delirium that lasts for hours, precluded its final acceptance. Later, phencyclidine was discovered to be a satisfactory anesthetic agent for certain animals, and is currently marketed for that purpose. A chemically related compound, ketamine hydrochloride (Ketalar) is employed as a human anesthetic. On the street, phencyclidine is known by some 20 names, including "Angel Dust," "PCP," and "Hog." Angel dust appears in many forms: as a crystalline powder, and as tablets and capsules in a variety of colors, shapes, and sizes. Angel dust is manufactured by kitchen chemists from readily available precursors. The procedure is not complicated and supplies are plentiful. This explains why phencyclidine is a common substitute for less available psychedelic drugs such as mescaline. An occasional batch