Endogenous N,N-Dimethyltryptamine and Sigma-1 Receptor Modulation as Enhancers of Neural-Substrate Coherence in the Swygert Theory of Everything AO (TSTOEAO)

A new quantitative model proposes that the body's own DMT, acting through sigma-1 receptors, can increase coherence between neural activity and an underlying substrate. The model integrates neuropharmacology and quantum biology to explain how sigma-1 receptor chaperone activity stabilizes microtubule coherence and improves phase alignment between brain oscillations and substrate eigenmodes. The paper provides a kinetic derivation, an experimental protocol, and five falsifiable predictions, all compatible with established biophysics. It suggests DMT is a biologically regulated modulator of neural-substrate phase coupling, offering a unified mechanism for altered-state phenomena.

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Abstract

This paper presents the first quantitative model linking endogenous N,N-dimethyltryptamine (DMT) and sigma-1 receptor (Sig-1R) modulation to measurable increases in neural-substrate coherence (α) within the Swygert Theory of Everything AO (TSTOEAO). The framework integrates neuropharmacology, quantum biology, and substrate-coupling dynamics to show how Sig-1R chaperone activity stabilizes microtubule coherence and enhances phase alignment between neural oscillations and substrate eigenmodes. A full kinetic derivation, an IRB-ready experimental protocol (ZERO-DMT-01), and five specific falsifiable predictions are provided. The model is fully compatible with established biophysics and offers immediate experimental pathways using EEG, heartbeat-evoked potentials, and Ganzfeld-based forced-choice tasks. This work establishes DMT as a biologically regulated modulator of neural-substrate phase coupling and proposes a unified mechanism underlying a range of altered-state phenomena.