Identification and Analysis of Lysergic Acid Diethylamide Analogs, 4‐Benzoyl‐ N,N ‐Diethyl‐7‐Methyl‐4,6,6a,7,8,9‐Hexahydroindolo[4,3‐ fg ]quinoline‐9‐Carboxamide (1Bz‐LSD) and N , N ‐Diethyl‐7‐Methyl‐4‐(4‐(Trimethylsilyl)Benzoyl)‐4,6,6a,7,8,9‐Hexahydroindolo[4,3‐ fg ]quinoline‐9‐Carboxamide (1‐TMSBz‐LSD), in tablet or paper sheet products available online in Japan
Rie Tanaka, Maiko Kawamura, Michiho Ito, Ruri Kikura‐hanajiri
Drug Testing and Analysis February 18, 2026 DOI: 10.1002/dta.70039 via OpenAlex
Summary
AI-generated from the abstractTwo new lysergic acid diethylamide (LSD) analogs, 1Bz-LSD and 1-TMSBz-LSD, were identified in tablet and paper sheet products sold in Japan. Using gas chromatography-mass spectrometry, liquid chromatography-photodiode array-mass spectrometry, liquid chromatography with hybrid quadrupole time-of-flight mass spectrometry, and nuclear magnetic resonance, the structures of the compounds were determined. 1Bz-LSD was found in a tablet product, and 1-TMSBz-LSD was found in a paper sheet product. This is the first report of these specific analogs being detected in such products in Japan.
Study at a glance
| Characteristics | Analytical chemistry study Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Identification biology Fact sheet Gas chromatography–mass spectrometry Chemistry |
| Key finding | Two LSD analogs, 1Bz-LSD and 1-TMSBz-LSD, were identified in tablet and paper sheet products in Japan for the first time. |
Abstract
Recently, many lysergic acid diethylamide (LSD) analogs have emerged as designer drugs worldwide. In Japan, these compounds are distributed as paper sheet or tablet products and are available online. Even after these compounds were regulated, new compounds with modified structures continued to appear. In the present study, two LSD analogs were identified from tablet or paper sheet products. Gas chromatography-mass spectrometry, liquid chromatography-photodiode array-mass spectrometry, liquid chromatography with hybrid quadrupole time-of-flight mass spectrometry, and nuclear magnetic resonance (NMR) measurement were used to determine the structures of the compounds. Based on these analyses, 4-benzoyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1Bz-LSD) and N,N-diethyl-7-methyl-4-(4-(trimethylsilyl)benzoyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1-TMSBz-LSD) were detected and identified in the tablet and paper sheet products, respectively. This paper is the first to report the detection of 1Bz-LSD and 1-TMSBz-LSD in tablet and paper sheet products in Japan.