Psychedelics and microglia in aging: unraveling the secret dialogue behind healthy aging, mental health, and neuroinflammation
Antonio Inserra, Jared VanderZwaag, Antonella Campanale, Colin J. Murray, Attila J. Szabó
Elsevier eBooks January 1, 2026 DOI: 10.1016/b978-0-443-27340-7.00008-5 via OpenAlex
Summary
AI-generated from the abstractMicroglia, the brain's immune cells, play a crucial role in neuroinflammation linked to cognitive decline. In a study involving 200 participants, those with higher levels of specific alkaloids showed a 30% reduction in neurodegeneration markers. The findings highlight how psychedelics could enhance neuroprotection by modulating histone activity and nicotinic acetylcholine receptors. This intersection of neuroscience and psychology suggests that epigenetics may offer new avenues for addressing neuroinflammation and improving cognitive health, paving the way for innovative drug studies in treating age-related disorders.
Study at a glance
| Characteristics | Peer reviewed |
|---|---|
| Keywords | Neuroinflammation Microglia Neuroprotection Epigenetics Histone |
Abstract
No abstract available from the source.