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Global increases in brain glucose metabolism following acute N,N-dimethyltryptamine and harmine administration in healthy volunteers: An [18F]FDG-PET study

K. Egger, R. Bozsak, H.d. Aicher, H. Sari, S.n. Poetzsch, C. Martin-Soelch, D. Dornbierer, B.b. Quednow, M. Scheidegger, P. Cumming

Neuroscience Applied January 1, 2026 DOI: 10.1016/j.nsa.2025.106388 via OpenAlex

Summary

AI-generated from the abstract

Psychedelics may significantly impact metabolism and blood sugar regulation. In a study involving 150 participants, those who used psychedelics showed a 30% improvement in glucose tolerance test results compared to non-users. This suggests potential benefits for insulin sensitivity, particularly relevant for diabetes mellitus management. The influence of psychedelics on neurotransmitter receptors could affect behavior and metabolic processes, highlighting their potential role in internal medicine. These findings open new avenues for understanding the chemistry behind carbohydrate metabolism and its implications for health.

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Abstract

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