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Psilocybin-assisted psychotherapy for psycho-existential distress in advanced cancer: a narrative review

Luca Magnani, Luca Ghirotto, Fabio Fesce, Tania Simona Re, Silvia Tanzi, Mario Amore, Alessandra Costanza

BMJ Supportive & Palliative Care February 18, 2026 DOI: 10.1136/spcare-2025-005689 via OpenAlex

Summary

AI-generated from the abstract

Psilocybin-assisted psychotherapy shows promise as a therapeutic option for palliative care, and further rigorous, interdisciplinary research is needed to ensure its implementation is grounded in anthropological and ethical considerations, extending its potential beyond oncology to other palliative settings.

Study at a glance

Characteristics Narrative review Peer reviewed
Population Patients with advanced cancer
Intervention Psilocybin-assisted psychotherapy
Keywords Psychotherapist Narrative review Psycho-oncology Palliative care Therapeutic relationship
Key finding Psilocybin-assisted psychotherapy is a compelling therapeutic option that warrants further investigation for ethically grounded implementation in palliative care beyond oncology.

Abstract

psilocybin-assisted psychotherapy is a compelling therapeutic option warranting further investigation through rigorous, interdisciplinary research to promote an anthropologically/ethically grounded implementation in palliative settings, even beyond the oncology field.

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