Effects of Esketamine on Postoperative Delirium and Postoperative Cognitive Function in Elderly Gastrointestinal Tumor Patients with Preoperative Anxiety
Jin Zha, Hao Chen, Zijie Sun, Rui Shi, Rufang Yan, Longmei Guo, Xiaoshu Chen, Xiaoying Lan, Huansen Huang, Lingzhi Wang
Drug Design Development and Therapy October 1, 2025 DOI: 10.2147/dddt.s528902 via OpenAlex
Summary
AI-generated from the abstractA low dose of intravenous esketamine (0.25 mg/kg) given during anesthesia induction to elderly patients with preoperative anxiety who are having gastrointestinal tumor surgery reduces the occurrence of postoperative delirium (POD) and enhances early cognitive function after surgery.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Elderly patients with preoperative anxiety undergoing gastrointestinal tumor surgery |
| Intervention | Esketamine |
| Dose | 0.25 mg/kg |
| Citations | 4 |
| Key finding | Administering low-dose intravenous esketamine (0.25 mg/kg) during anesthesia induction decreases the incidence of POD and improves early postoperative cognitive function in elderly patients with preoperative anxiety having gastrointestinal tumor surgery. |
Abstract
In elderly patients with preoperative anxiety who undergo gastrointestinal tumor surgery, administering a low-dose intravenous esketamine injection (0.25 mg/kg) during anesthesia induction can decrease the incidence of POD and improve early postoperative cognitive function.