Treatment With (Es)ketamine in Catatonia
Pim B. van der Meer, Sebastiaan O Verboeket, Arjen J. C. Slooter, Jan W. Schoones, Martijn S. van Noorden, Metten Somers, Albert Batalla, Annemiek Dols
The Journal of Clinical Psychiatry October 13, 2025 DOI: 10.4088/jcp.25br15940 via OpenAlex
Summary
AI-generated from the abstractNMDA receptor antagonists like ketamine may help treat catatonia. This systematic review evaluated the efficacy and safety of ketamine and esketamine for catatonia, finding that the available evidence suggests these drugs could be beneficial, but the data are limited and further research is needed to confirm their role.
Study at a glance
| Characteristics | Systematic review Peer reviewed |
|---|---|
| Interventions | Ketamine Esketamine |
| Topics | Ketamine |
| Keywords | Catatonia Nmda receptor Medline Meta-analysis |
| Key finding | Ketamine and esketamine may be beneficial for catatonia, but the evidence is limited and more research is needed. |
Abstract
Recent evidence suggests that NMDA receptor antagonists, such as ketamine, may offer benefit in catatonia. This systematic review was conducted to evaluate the efficacy and safety of ketamine and esketamine for catatonia.