Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials
Frontiers in Pharmacology December 1, 2025 DOI: 10.3389/fphar.2025.1708221 via OpenAlex
Summary
AI-generated from the abstractEsketamine provides relatively good pain control after surgery and is linked to a lower risk of postpartum depression, but this finding is not stable. In pregnant women over 30, esketamine may increase the risk of dizziness. The study was conducted entirely in China, which limits how broadly the results apply.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Pregnant women in China |
| Intervention | Esketamine |
| Topics | Ketamine |
| Keywords | Medicine Randomized controlled trial Anesthesia Pain control |
| Key finding | Esketamine shows favorable efficacy for postoperative analgesia and is associated with a lower risk of postpartum depression, but the result is unstable and may increase dizziness in pregnant women over 30. |
Abstract
As a therapy for postoperative analgesia, esketamine shows relatively favorable efficacy in pain control and is associated with a lower risk of postpartum depression. However, this result is unstable. Furthermore, esketamine may increase the risk of dizziness in pregnant women aged over 30 years. Since all the experiments in this study are conducted in China, there are certain regional limitations.