THE DISTRIBUTION AND METABOLISM OF LYSERGIC ACID DIETHYLAMIDE
Julius Axelrod, Roscoe O. Brady, B. Witkop, Edward V. Evarts
Annals of the New York Academy of Sciences March 1, 1957 DOI: 10.1111/j.1749-6632.1957.tb40739.x via OpenAlex
Summary
AI-generated from the abstractIn the late 1950s, Axelrod investigated how the body processes lysergic acid diethylamide (LSD), examining its distribution, excretion, and rate of biotransformation. He detailed the subcellular processes involved in transforming LSD, determined the order of drug concentrations in various tissues, and found that the body almost completely metabolizes the drug. Additionally, he discovered considerable differences between animal species in the rate of LSD biotransformation.
Study at a glance
| Characteristics | Laboratory study Peer reviewed |
|---|---|
| Population | Various animal species |
| Intervention | LSD |
| Keywords | Public health Welfare Mental health Family medicine Gerontology |
| Citations | 154 |
| Key finding | LSD is almost completely metabolized by the body, with considerable differences between animal species in the rate of biotransformation. |
Abstract
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.