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Lysergic Acid Diethylamide

Donald B. Louria

New England Journal of Medicine February 22, 1968 DOI: 10.1056/nejm196802222780806 via OpenAlex

Summary

AI-generated from the abstract

Lysergic acid diethylamide (LSD) has sparked more public debate than any other drug. This review summarizes its pharmacology, medical uses, and dangers. Claims that indiscriminate or uncontrolled use of LSD enhances aesthetic sensitivity, creativity, love, transcendental experiences, insights, or aphrodisiac effects are not substantiated; objective data strongly suggest that claims of augmented aesthetic sensitivity and creativity are false.

Study at a glance

Characteristics Review Peer reviewed
Topics LSD Serotonin
Keywords Pharmacology Internal medicine Biochemistry Receptor
Citations 69
Key finding Claims that LSD enhances aesthetic sensitivity and creativity are not substantiated and are contradicted by objective data.

Abstract

NO drug used by man has stimulated greater public-debate than lysergic acid diethylamide (LSD). This brief review of the current status of the drug will summarize its pharmacology, medical uses and dangers. No attempt will be made to analyze in detail its alleged benefits when taken indiscriminately or under uncontrolled circumstances; these include augmented aesthetic sensitivity, enhanced creativity, increased capacity for love, occurrence of transcendental experiences, acquisition of new insights and aphrodisiac effects. Suffice it to say that none of these claims are substantiated. Indeed, objective data now strongly suggest that claims of augmented aesthetic sensitivity and creativity cannot be . . .

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