Combined intoxication with methylone and 5-MeO-MIPT
Eiji Shimizu, Hiroyuki Watanabe, Takashi Kojima, Hiroko Hagiwara, Mihisa Fujisaki, Ryosuke Miyatake, Kenji Hashimoto, Masaomi Iyo
Progress in Neuro-Psychopharmacology and Biological Psychiatry July 30, 2006 DOI: 10.1016/j.pnpbp.2006.06.012 via OpenAlex
Summary
AI-generated from the abstractA 27-year-old man experienced substance intoxication after a single ingestion of what he believed was pure methylone powder purchased online. Chemical analysis revealed the powder contained about 60% methylone (120 mg) and 38% 5-MeO-MIPT (76 mg), a mixture not disclosed to the user. The case highlights that clinicians should be alert to intoxication from these agents and that substance-related mental disorders may be complicated by the combined use of multiple psychoactive drugs, especially when the actual composition of purchased drugs is unknown.
Study at a glance
| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 27-year-old male patient |
| Dose | 120 mg methylone and 76 mg 5-MeO-MIPT |
| Keywords | Designer drug Mephedrone Hallucinogen Ingestion Pharmacology |
| Citations | 103 |
| Key finding | A single ingestion of a mixture of methylone and 5-MeO-MIPT caused substance intoxication, and the drug's composition differed from what was advertised. |
Abstract
Although preclinical studies suggest that methylone (2-methylamino-1-[3,4-methylenedioxyphenyl]propan-1-one) and 5-MeO-MIPT (5-methoxy-N-methyl,N-isopropyl tryptamine) may have psychostimulant properties, the scientific reports about the clinical effects of these agents are scant. We describe a 27-year-old male patient with substance intoxication after a single ingestion of the mixture of methylone and 5-MeO-MIPT. Though he bought the drug as pure methylone powder via an internet order, our chemical analyses indicated that the drug was composed of about 60% methylone (120 mg) and 38% 5-MeO-MIPT (76 mg). This case report suggests that clinicians should be alert to the possibility of the emergence of methylone or 5-MeO-MIPT intoxication, and substance-related mental disorder may be complicated by combined use of other psychoactive drugs.