Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.
Lorenzo Pasquini, Jakub Vohryzek, Anira Escrichs, Yonatan Sanz Perl, Adrián Ponce‐alvarez, Sebastián Idesis, Manesh Girn, Leor Roseman, Jennifer M. Mitchell, Adam Gazzaley, Morten Kringelbach, David J. Nutt, Taylor Lyons, Robin L. Carhart‐Harris, Gustavo Deco
Hum Brain Mapp July 1, 2026 DOI: 10.1002/hbm.70596 via PubMed
Summary
AI-generated from the abstractA computational model predicts that a single dose of psilocybin can produce lasting changes in the dynamic activity and effective connectivity of fronto-striatal-thalamic brain circuits. The modeling suggests that psilocybin may strengthen connectivity between the prefrontal cortex and striatum while altering thalamic gating, effects that persist beyond the acute drug experience. These changes could underlie the sustained therapeutic benefits observed in clinical settings, such as reduced depressive symptoms and increased psychological flexibility. The findings provide a mechanistic framework for understanding how psilocybin induces long-term neural plasticity and highlight potential circuit targets for treating psychiatric disorders.
Study at a glance
| Characteristics | Computational modeling study Peer reviewed |
|---|---|
| Key finding | Modeled psilocybin exposure produces lasting alterations in fronto-striatal-thalamic circuit dynamics and effective connectivity, suggesting a neural mechanism for sustained therapeutic effects. |
Abstract
Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.