PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin.
Leonardo Novelli, Devon Stoliker, Tamrin Barta, Matthew D Greaves, Sidhant Chopra, James Jackson, Jessica Kwee, James C Pang, Martin L Williams, Adeel Razi
Scientific data May 21, 2026 DOI: 10.1038/s41597-026-07312-1 via PubMed
Summary
AI-generated from the abstractPsiConnect is a large-scale neuroimaging study that investigates how psilocybin affects brain activity and subjective experience depending on context. Sixty-two participants received a 19 mg dose of psilocybin and underwent functional, structural, and diffusion-weighted MRI, as well as EEG, before and after administration. Scans included resting-state and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the participants completed an 8-week meditation training program, allowing examination of interactions between meditation, psilocybin, and brain function. Multi-echo fMRI improved signal quality. Behavioral and self-report measures captured acute and long-term effects, with follow-ups up to one year. Data is openly shared to support future research.
Study at a glance
| Characteristics | Observational cohort Longitudinal Peer reviewed |
|---|---|
| Sample size | 62 |
| Population | Healthy adults |
| Interventions | Psilocybin Meditation training |
| Dose | 19 mg |
| Duration | 8-week meditation training, follow-ups to one year post-administration |
| Key finding | The study provides a comprehensive, multimodal dataset to examine context-dependent neural and subjective effects of psilocybin, including interactions with meditation training and long-term follow-up. |
Abstract
PsiConnect is a large-scale neuroimaging study designed to investigate context-dependent neural and subjective effects of psilocybin using multimodal neuroimaging. It combines functional, structural, and diffusion-weighted MRI with EEG to examine brain activity in 62 participants before and after a 19 mg dose of psilocybin. The design includes resting-state scans and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the cohort underwent an 8-week meditation training program, enabling exploration of interactions among meditation, psilocybin, and brain function. fMRI data was obtained through multi-echo fMRI, enhancing signal-to-noise ratio and reducing susceptibility artifacts to improve reliability. A comprehensive battery of behavioural and self-report measures captured acute and longitudinal cognitive and subjective effects, with follow-ups to one year post-administration. The large sample, multimodal imaging, contextual diversity, and behavioural follow-ups enable study of psilocybin-induced brain and behaviour changes with unprecedented comprehensiveness and reliability. Data is curated according to open science principles to ensure accessibility and compatibility with established neuroimaging pipelines, making PsiConnect a valuable, reusable resource for cognitive and computational neuroscience.