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Transient or transformative? Psychedelics, agency and informed consent

Chiara Caporuscio

Journal of Medical Ethics March 10, 2026 DOI: 10.1136/jme-2025-111248 via OpenAlex

Summary

AI-generated from the abstract

The transformative potential of psychedelic experiences raises ethical concerns about informed consent in psychedelic-assisted therapy, because an altered state of consciousness might shift a person's values in ways they cannot foresee. This argument, however, overemphasizes the power of the psychedelic experience itself. In most cases, the altered state is only the start; lasting change requires a sober, authentic agential process afterward. This two-step view of transformation alleviates the pressure on informed consent, suggesting that consent before the experience can still be valid.

Study at a glance

Characteristics Theoretical or philosophical paper Peer reviewed
Keywords Transformative learning Informed consent Agency philosophy Consciousness Power physics
Key finding Psychedelic-mediated transformation requires a sober, agential process after the experience, which alleviates concerns about the validity of informed consent.

Abstract

The literature on psychedelic experiences often highlights their transformative potential. This raises ethical questions about informed consent in psychedelic-assisted therapy: if the altered state of consciousness induced by psychedelic drugs can profoundly alter a person's value system in ways that are epistemically inaccessible to them beforehand, it is unclear whether their informed consent before the experience can be considered valid. I argue that this view stems from a simplistic understanding of psychedelic-mediated transformation, which overemphasises the power of the psychedelic experience in driving change. In most psychedelic-mediated changes, the experience of an altered state of consciousness is only the beginning of the transformative process: a lasting transformation requires patients to undertake a sober, authentic agential process following the psychedelic experience. I suggest that this two-step view of psychedelic transformation alleviates the pressure on informed consent.

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