Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders

N,N-dimethyltryptamine (DMT), a naturally occurring psychedelic compound, shows promise for treating psychiatric conditions such as depression, anxiety, and addiction, as well as neurodegenerative disorders like Alzheimer's and Parkinson's disease. DMT acts primarily on serotonin receptors, particularly the 5-HT2A subtype, and also interacts with sigma-1 receptors, which may contribute to neuroprotective and anti-inflammatory effects. The review discusses DMT's mechanisms, including its ability to promote neuroplasticity and reduce neuroinflammation. While preclinical evidence is encouraging, the authors note that clinical research remains limited, and further studies are needed to establish safety and efficacy in humans.

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Abstract

AMA Schimmelpfennig J, Jankowiak-Siuda K. Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii. 2023;39(2):115-130. doi:10.5114/fpn.2023.131979. APA Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023). Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii, 39(2), 115-130. https://doi.org/10.5114/fpn.2023.131979 Chicago Schimmelpfennig, Jakub, and Kamila Jankowiak-Siuda. 2023. "Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders". Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii 39 (2): 115-130. doi:10.5114/fpn.2023.131979. Harvard Schimmelpfennig, J., and Jankowiak-Siuda, K. (2023). Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii, 39(2), pp.115-130. https://doi.org/10.5114/fpn.2023.131979 MLA Schimmelpfennig, Jakub et al. "Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders." Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii, vol. 39, no. 2, 2023, pp. 115-130. doi:10.5114/fpn.2023.131979. Vancouver Schimmelpfennig J, Jankowiak-Siuda K. Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii. 2023;39(2):115-130. doi:10.5114/fpn.2023.131979.