Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats
Alena Lemeshova, Feysal Abdirahaman, Haney Haidari, Cherish Zhao, Aiman Limbada, Jennifer A. Honeycutt
bioRxiv July 1, 2026 DOI: 10.64898/2026.06.26.734907
Summary
AI-generated from the abstractA single dose of ketamine reduces anxiety for an extended period in female Wistar Kyoto rats, even though it increases oxidative stress in the brain. The anxiolytic effect persists long after the drug is cleared, suggesting that the initial oxidative stress does not prevent the lasting behavioral benefit.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Female Wistar Kyoto rats |
| Intervention | Ketamine |
| Key finding | Acute ketamine produces long-term anxiolytic effects in female Wistar Kyoto rats despite increasing oxidative stress. |
Abstract
Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats