Early suicidal ideation change and suicidality-associated emergency department utilization after ketamine or esketamine treatment in treatment-resistant depression.
Liliana Patarroyo-Rodriguez, Vanessa K. Pazdernik, Jennifer L. Vande Voort, Simon Kung, Balwinder Singh
Ther Adv Psychopharmacol May 22, 2026 DOI: 10.1177/20451253261450747 via PubMed Central
Summary
AI-generated from the abstractAmong people with treatment-resistant depression, early changes in suicidal ideation after ketamine or esketamine treatment are linked to later emergency department visits for suicidality. The analysis indicates that reductions in suicidal thoughts during the first few weeks of treatment may lower the risk of subsequent emergency care for suicidality, though the relationship requires further study.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | People with treatment-resistant depression receiving ketamine or esketamine treatment |
| Interventions | Ketamine Esketamine |
| Key finding | Early reduction in suicidal ideation after ketamine or esketamine treatment is associated with lower rates of emergency department visits for suicidality. |
Abstract
Early suicidal ideation change and suicidality-associated emergency department utilization after ketamine or esketamine treatment in treatment-resistant depression.