Ketamine Mechanism
September 30, 2019 DOI: 10.64239/pi-qt0702
Summary
AI-generated from the abstractKetamine's antidepressant effects may depend on the opioid system rather than solely the NMDA receptor. When opiate receptors were blocked with naltrexone, the antidepressant effect was prevented, suggesting that the opioid system plays a key role in ketamine's action.
Study at a glance
| Characteristics | Preprint |
|---|---|
| Key finding | Blocking opiate receptors with naltrexone prevented ketamine's antidepressant effect, indicating that the opioid system may mediate these effects. |
Abstract
Ketamine’s antidepressant effects, previously thought to involve the NMDA receptor, may be produced through the opioid system (because blocking opiate receptors with naltrexone blocked the antidepressant effect).