Adjunctive Ketamine With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder
March 25, 2022 DOI: 10.64239/pi-qt3704
Summary
AI-generated from the abstractA small pilot trial found that combining ketamine with mindfulness psychotherapy led to higher rates of sustained abstinence from alcohol compared to a placebo combined with alcohol psychoeducation. Other combinations of the therapies did not show significant differences from each other. Adverse effects were minimal, indicating that current alcohol use should not prevent consideration of ketamine treatment.
Study at a glance
| Characteristics | Pilot trial Pilot study |
|---|---|
| Population | People with alcohol use disorder |
| Interventions | Ketamine mindfulness psychotherapy placebo alcohol psychoeducation |
| Key finding | Ketamine plus mindfulness psychotherapy was more effective for sustained abstinence from alcohol than placebo plus alcohol psychoeducation. |
Abstract
Ketamine plus mindfulness psychotherapy was more effective for sustained abstinence from alcohol than placebo plus alcohol psychoeducation. Other combinations of these therapies were not significantly different from one another in this small pilot trial (N=20-25 in each group). Adverse effects were minimal, suggesting that current alcohol use is not a contraindication for consideration of ketamine.