Toward Translatable Biomarkers of Psychedelic-Induced Neuroplasticity.
The American journal of psychiatry January 1, 2025 DOI: 10.1176/appi.ajp.20231054 via PubMed
Summary
AI-generated from the abstractPsychedelics promote cortical neuron growth in the prefrontal cortex in preclinical studies, but measuring this structural plasticity in humans has been difficult. New positron emission tomography imaging advances could enable measurement of synaptic proteins after psychedelic administration. A translatable biomarker of psychedelic-induced neuroplasticity would help stratify patients, determine optimal dosing, and aid discovery of novel compounds with similar effects on structural neuroplasticity.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Ketamine Neuroplasticity |
| Keywords | Sv2a Psychoplastogen Psychedelics/hallucinogens/entheogens Neuroscience/brain-research/neurobiology |
| Citations | 8 |
| Key finding | New advances in PET imaging could enable measurement of synaptic proteins in humans following psychedelic administration, providing a translatable biomarker of psychedelic-induced neuroplasticity. |
Abstract
Numerous preclinical studies have demonstrated that psychedelics promote the growth of cortical neurons in the prefrontal cortex. However, measuring psychedelic-induced structural plasticity in humans has remained a challenge. New advances in positron emission tomography imaging could facilitate the measurement of synaptic proteins in humans following psychedelic administration. Identifying a translatable biomarker of psychedelic-induced neuroplasticity would enable patient stratification and determination of optimal dosing paradigms while also facilitating the discovery of novel compounds that produce similar effects on structural neuroplasticity.