Merits and demerits of administering esketamine in preventing postpartum depression following cesarean section.
World journal of clinical cases December 26, 2024 DOI: 10.12998/wjcc.v12.i36.6883 via PubMed
Summary
AI-generated from the abstractEmergency cesarean section is linked to postpartum depression. While esketamine shows rapid antidepressant effects, and trials support its use to prevent postpartum depression after elective cesarean sections, the evidence does not cover emergency procedures. Esketamine carries a dose-dependent risk of psychotic symptoms like hallucinations, so it should be used cautiously in cesarean settings only when benefits outweigh risks.
Study at a glance
| Characteristics | Review Randomized Peer reviewed |
|---|---|
| Intervention | Esketamine |
| Topics | Depression Esketamine |
| Keywords | Adverse event Cesarean section Medial prefrontal cortex Postpartum depression ppd |
| Citations | 1 |
| Key finding | Esketamine may prevent postpartum depression after elective cesarean sections, but its use in emergency cesarean sections requires caution due to risks of psychotic symptoms. |
Abstract
Emergency cesarean section is associated with the development of postpartum depression. Esketamine has been demonstrated to have a rapid onset of antidepressant effects. Randomized controlled trials and meta-analyses have demonstrated the efficacy of esketamine in preventing postpartum depression after cessarean section. However, the data included in these analyses were derived from elective cesarean sections and differed in the dose and timing of esketamine administration. Esketamine is a dissociative anesthetic with a dose-dependent risk of inducing psychotic symptoms, including hallucinations. In the setting of cesarean section, esketamine should be administered with caution and only if the potential benefits outweigh the risks.