The identification of LSD-like hallucinogens using the chronic spinal dog.

In chronic spinal dogs, several indoleamines and phenethylamines were tested and compared to LSD and amphetamine. Psilocin, mescaline, dimethyltryptamine, and tryptamine acted like LSD. DOM, DOB, DMA, and TMA were mostly LSD-like but had some amphetamine-like effects. PMA and PEA were mainly amphetamine-like with some LSD-like activity. MMDA and MDA showed a mix of LSD and amphetamine properties plus additional unique actions, suggesting other modes of action. Antagonists like phenoxybenzamine and cyproheptadine were used to study effects, and some drugs were also tested in LSD-tolerant dogs and for appetite suppression.

Study at a glance

Abstract

The effects of several indoleamines and phenethylamines were studied in the chronic spinal dog and compared with two standard drugs, LSD and amphetamine. In the nontolerant chronic spinal dog, their effects on a variety of physiologic and behavioral functions were measured in untreated dogs, as well as dogs treated with certain antagonists. The effects of the antagonists phenoxybenzamine and cyproheptadine on the various physiologic effects were studied for all drugs. For some idoleamines and phenethylamines, the effects of chlorpromazine and pimozide were also studied. Indoleamines and phenethylamines in the LSD-tolerant chronic spinal dog and their anorexigenic effects in the intact dog were also studied. The results of these studies indicate that psilocin, mescaline, dimethyltryptamine and tryptamine are LSD-like drugs. DOM, DOB, DMA, and TMA are predominantly LSD-like drugs but do have some amphetamine-like action. PMA and PEA are predominantly amphetamine-like drugs with some LSD-like activity. MMDA and MDA have a more complicated pharmacology showing proerties that resemble LSD and amphetamine, but they have other actions which are not shared by either LSD or amphetamine, which suggests they have yet other modes of action.