Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG).
W Dimpfel, M Spüler, D E Nichols
Psychopharmacology January 1, 1989 DOI: 10.1007/bf00451678 via PubMed
Summary
AI-generated from the abstractHallucinogenic amphetamine derivatives (R-DOB, R-DOM, R-DOI) and nonhallucinogenic amphetamine derivatives (S-MBDB, S-MDMA, S-amphetamine) produce distinct brain activity patterns in freely moving rats. Nonhallucinogens generally decreased power in field potentials across frontal cortex, hippocampus, striatum, and reticular formation, with the most prominent changes in alpha2 and delta frequency bands. In contrast, hallucinogens increased power specifically in the alpha1 frequency band, especially in the striatum. Because increases in alpha1 power have been linked to serotonergic control mechanisms, these results support the hypothesis that 5-HT2 receptors, which are abundant in the striatum, may be involved in the hallucinogenic action of drugs.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Freely moving rats |
| Interventions | R-DOB R-DOM R-DOI S-MBDB S-MDMA |
| Citations | 42 |
| Key finding | Hallucinogenic amphetamine derivatives increased alpha1 power in the striatum, whereas nonhallucinogenic derivatives decreased power across frequency bands, suggesting a role for striatal 5-HT2 receptors in hallucinogenic action. |
Abstract
Telemetric recordings of field potentials from frontal cortex, hippocampus, striatum and reticular formation of freely moving rats were analysed before and after injection of the enantiomeric hallucinogenic amphetamine derivatives R-DOB [(-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane], R-DOM [(-)-1-(2,5-dimethoxy-4-methylphenyl)-2-amino-propane] and R-DOI [(-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane] as well as the nonhallucinogenic amphetamine derivatives S-MBDB [(+)-N-methyl-1-(1,3-benzodioxol-5-yl)butanamine] and S-MDMA [(+)-3,4-methylenedioxymethamphetamine] and S-(+)-amphetamine. The frequency analysis of the field potentials revealed a clearcut difference between them. The spectral patterns emerging after injection of the non-hallucinogens were characterized by a general decrease of power, the changes in the alpha2 and delta band being the most prominent, whereas only after the application of the hallucinogenic compounds was a contrasting increase of power observed in the alpha 1 frequency band, especially in the striatum. As increases in alpha 1 power have been correlated in the same pharmacological model to serotonergic control mechanisms, the results are in line with the hypothesis that 5-HT2 receptors, predominantly occurring in the striatum, might be involved in the hallucinogenic action of drugs.