Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging—From Depression to Neurodegeneration
Marta Jóźwiak-Bębenista, Anna Stasiak, Monika Sienkiewicz, Paweł Kwiatkowski, Edward Kowalczyk
Preprints.org April 15, 2026 preprint DOI: 10.20944/preprints202604.1125.v1
Summary
AI-generated from the abstractThis review examines the potential therapeutic use of psilocybin in older adults for inflammation-driven disorders of aging, including depression and neurodegeneration. It discusses how psilocybin may modulate inflammatory pathways and promote neuroplasticity, offering benefits for age-related conditions where inflammation plays a key role. The authors suggest that psilocybin-assisted therapy could address both mood disorders and cognitive decline in this population, though they note the need for further research to establish safety and efficacy in older adults.
Study at a glance
| Characteristics | Review |
|---|---|
| Population | Older adults |
| Key finding | Psilocybin may offer therapeutic benefits for inflammation-driven disorders of aging in older adults, such as depression and neurodegeneration, by modulating inflammatory pathways and promoting neuroplasticity. |
Abstract
Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging—From Depression to Neurodegeneration