0414 The Interaction of Historical Psychedelic Use and Time Spent in Bed on Sleep Architecture

People who have used psychedelic drugs at any point show small differences in objective sleep patterns measured by Fitbit devices compared with non-users. Users averaged 406 minutes in bed and non-users 405 minutes. Psychedelic use predicted more total sleep time, less REM sleep, more light sleep, and more deep sleep, but the effect sizes were negligible. The study analyzed data from 21,076 adults in the All of Us research database, of whom 7,799 reported psychedelic use and 13,277 did not. The findings suggest that while statistically significant differences exist, their practical importance is minimal.

Study at a glance

Abstract

Abstract Introduction Approximately 12% of U.S. adults report having used any type of psychedelic at some point in their lives, making it one of the most widely used recreational drugs. There exists a need for a better understanding of the consequences of use on objective sleep habits. Research on psychedelics effects on sleep indicate increased sleep duration, increased REM latency, and decreased slow wave sleep occur during and immediately after the post trip phase. The purpose of this study was to determine if psychedelic use was predictive of changes in total sleep time, time spent in each stage of sleep (REM, light, deep), and time spent awake and to describe sleep differences in users vs. non-users Methods Data were obtained from the All of Us research data base (n=21,076; Mean age = 56.55; Female= 67.3%). Participants indicated any type of psychedelic use and were grouped into users and non-users based on a yes (n=7,799) or no (n=13,277) response. Objective sleep measures included Fitbit sleep data to include number of minutes spent in each stage of sleep (REM, light, deep), minutes spent awake, and total sleep time in minutes. Results Data suggest that the interaction of history of psychedelic use and minutes spent in bed (users = 406 minutes; non-users = 405 minutes) predicts more time spent asleep (t=230.119, p<.001), less time spent in REM sleep (t=-256.7, p<.001), greater time spent in light sleep (t=176.58, p<.001), and increased time spent in deep sleep (t=177.71, p<.001). Additionally, small group differences were found between users and non-users on measures of total sleep time in minutes (t=19.075, p<.001; ES= 0.0087), minutes spent in REM sleep (t=-8.725, p<.001; ES= -0.0052), minutes spent in light sleep (t=30.262, p<.001; ES= 0.018), minutes spent in deep sleep (t=-33.701, p<.001; ES= -0.020) and minutes spent awake (t=7.43, p<.001; ES= 0.0044), however effect sizes were negligible. Conclusion Data suggests changes in objective sleep habits occur in those who use psychedelic drugs regardless of time of use. Differences in sleep staging among users was negligible. Support (if any) JAB’s time was supported by a Center Grant from the National Institute of Minority Health and Health Disparities (Grant # U54MD01595)