Lysergic Acid Diethylamide: Review and Collaborative Study
Journal of AOAC INTERNATIONAL November 1, 1968 DOI: 10.1093/jaoac/51.6.1318
Summary
AI-generated from the abstractA collaborative study involving 11 collaborators tested a method for identifying and measuring lysergic acid diethylamide (LSD). The presumptive test proved useful for quick preliminary checks. Racemization aided identification through paper chromatography. Assay recovery based on the Sandoz LSD-25 reference standard was 98.0%, and based on Ergonovine Maleate USP Reference Standard it was 96.5%. The method is recommended for adoption as official, first action.
Study at a glance
| Characteristics | Collaborative study Peer reviewed |
|---|---|
| Key finding | The assay method for LSD achieved 98.0% recovery using Sandoz LSD-25 reference standard and 96.5% using Ergonovine Maleate USP Reference Standard. |
Abstract
Abstract A method for identification and determination of lysergic acid diethylamide (LSD) was studied collaboratively by 11 collaborators on three samples prepared by the Associate Referee. The presumptive test is a valuable tool for rapid preliminary examination. Racemization of the LSD adds further to its identification by paper chromatography. Assay recovery, based on Sandoz LSD-25 reference standard, was 98.0%. Recovery by the same assay, but based on Ergonovine Maleate USP Reference Standard, was 96.5%. The method is recommended for adoption as official, first action.