ChemInform Abstract: STUDIES ON LYSERGIC ACID DIETHYLAMIDE AND RELATED COMPOUNDS PART 3, INPROVEMENT OF AMIDATION OF LYSERGIC ACID
Chemischer Informationsdienst August 20, 1974 DOI: 10.1002/chin.197433454
Summary
AI-generated from the abstractAmidation of lysergic acid (I) using triphenyl phosphite/imidazole/phosphoric acid tris-(dimethylamide) or phosphoric acid tris-(dimethylamide)/tosyl chloride yields compounds (II) and (III). With the latter reagent, compounds (II) are obtained in 68-75% yield and compounds (III) in up to 3-8% yield.
Study at a glance
| Characteristics | Peer reviewed |
|---|---|
| Key finding | Amidation of lysergic acid with phosphoric acid tris-(dimethylamide)/tosyl chloride gives compounds (II) in 68-75% yield and compounds (III) in up to 3-8% yield. |
Abstract
AbstractDie Amidierung von Lysergsäure (I) in Gegenwart von Triphenylphosphit/Imidazol/ Phosphorsäure‐tris‐(dimethylamid) oder Phosphorsäure‐tris‐(dimethylamid)/Tosyl= Chlorid liefert die Verbindungen (II) und (III), wobei bei Verwendung des letztgenanr ten Reagens die Verbindungen (II) in 68‐75%iger und die Verbindungen (III) in bis 3 zu 8%iger Ausbeute erhalten werden.