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Is Cannabidiol (CBD) a Non-Psychoactive Phytocannabinoid?

Eliana Rodrigues

Psychoactives February 3, 2026 DOI: 10.3390/psychoactives5010004 via OpenAlex

Summary

AI-generated from the abstract

Interest in psychoactive substances like psychedelics is growing in medicine and academia, but misclassifications of certain plants, animals, fungi, and their substances persist in media and scholarly circles. This opinion piece argues whether cannabidiol (CBD) is a non-psychoactive phytocannabinoid, noting that hundreds of robust studies support its clinical use for seizures, anxiety, psychosis, schizophrenia, post-traumatic stress disorder, and addiction. The text reviews historical classifications of psychoactive substances, reflects on terminology, and proposes a new classification for psychedelics.

Study at a glance

Characteristics Opinion piece Peer reviewed
Topics CBD
Keywords Scientific literature Medline Mechanism biology Drug
Key finding CBD may be misclassified as non-psychoactive, given its clinical effects on psychiatric conditions, and the text proposes a revised classification for psychedelics.

Abstract

Interest in psychoactive substances, including psychedelics, is rapidly expanding in medical, academic, and other popular fields. Despite the classifications established within the psychopharmacological scientific community, certain plants, animals, and fungi, as well as the substances obtained from them, have been misclassified by both the media and academic circles. This opinion piece aims to present arguments to answer the following question: Is CBD a non-psychoactive phytocannabinoid? Hundreds of robust scientific studies published in recent years involving CBD have strengthened its clinical use in the treatment of seizures, anxiety, psychosis, schizophrenia, post-traumatic stress disorder, and addiction. As part of the arguments to answer the question posed, this text provides a historical overview of the classifications of psychoactive substances available to date, and offers reflections on these terminologies and a proposed classification of psychedelics.

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