A Case Report of Ketamine-induced Hypoglycemia in Treatment Resistance Depression.
Juthawadee Lortrakul, Keerati Pattanaseri
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology August 31, 2024 DOI: 10.9758/cpn.23.1155 via PubMed
Summary
AI-generated from the abstractKetamine therapy can reduce suicide risk and depression in treatment-resistant patients, but its adverse effects include blurred vision, nausea, hepatotoxicity, headache, and cystitis. The effect on blood glucose is unclear. A 36-year-old man with type 1 diabetes mellitus experienced recurrent hypoglycemia episodes after ketamine infusion for treatment-resistant depression, despite no severe hypoglycemia in the prior 20 years. His depression improved with ketamine, but clinicians should monitor for hypoglycemia when initiating ketamine infusion in patients with type 1 diabetes.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 36-year-old man with type 1 diabetes mellitus and treatment-resistant depression |
| Intervention | Ketamine infusion |
| Topics | Depression Ketamine |
| Keywords | Adverse drug event Hypoglycemia Ketamine therapy Adverse drug reactions |
| Citations | 1 |
| Key finding | Ketamine infusion was associated with recurrent hypoglycemia episodes in a patient with type 1 diabetes mellitus. |
Abstract
Ketamine therapy can reduce the risk of suicide and depression in the treatment resistant patient. Adverse effects of ketamine infusion include blurred vision, nausea and vomiting, hepatotoxicity, headache, and cystitis. However, the effect of ketamine infusion on blood glucose remains unclear. This report describes several episodes of hypoglycemia in a 36-year-old man with type 1 diabetes mellitus after ketamine infusion for treatment-resistance depression. He has been receiving subcutaneous insulin injection and denied any severe hypoglycemia events in the prior 20 years. He had unsuccessful treatment for depression. His depressive conditions were subsequently improved due to ketamine therapy, however, he had recurrent hypoglycemia episodes. Clinicians should be aware of this potential adverse effect on initiating ketamine infusion with patients who had type 1 diabetes.