Psychotropic Drugs Reemerging as Headache Medicines.

Interest in using psychedelics and other psychoactive compounds to treat headache disorders is increasing. Although people have long reported therapeutic benefits from these substances, formal clinical trials have only recently begun. The effectiveness of any treatment depends on the specific headache disorder, the particular drug, and how it is used; no single protocol works for all headaches or drugs. This article discusses the careful considerations needed when evaluating classic psychedelics, ketamine, and cannabinoids as potential headache medicines.

Study at a glance

Abstract

Scientific and public attention on the therapeutic effects of psychedelics and other psychoactive compounds in headache disorders has recently grown. The use and reported therapeutic effects of such treatments have long been reported, though formal clinical trials are only recently taking place. When considering how these substances might be further studied and eventually applied, it is important to consider the specific headache disorder, the particular drug, and the mode of use. No singular protocol will be applicable across all headache disorders and drugs. In this leading article, the nuance required to consider the value of classic psychedelics, ketamine, and cannabinoids as headache medicines is presented.