Disorders due to Substance Use: Hallucinogens and MDMA-Related Substances
Sandeep M. Nayak, Matthew W. Johnson
Tasman’s Psychiatry January 1, 2023 DOI: 10.1007/978-3-030-42825-9_94-1 via Springer Nature
Summary
AI-generated from the abstractHallucinogens include a wide range of substances with different effects and risks. This chapter examines disorders caused or worsened by two classes: classic psychedelics like LSD and psilocybin, which work mainly through 5HT_2A receptors, and MDMA. It reviews evidence on adverse effects such as acute toxicity, abuse potential, persistent perceptual disturbances (Hallucinogen Persisting Perception Disorder), psychosis, and neurotoxicity.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | MDMA |
| Keywords | Psychedelic Hallucinogen Disorders Harm |
| Key finding | Classic psychedelics and MDMA are associated with a range of adverse effects including acute toxicity, abuse potential, persistent perceptual effects, psychosis, and neurotoxicity. |
Abstract
Hallucinogens are a broad category of substances encompassing drugs with diverse pharmacological, phenomenological, and adverse effects. In this chapter, the focus is on disorders caused by and exacerbated by two classes of hallucinogens. These are classic psychedelics (drugs including LSD and psilocybin that exert subjective effects principally by 5HT_2A agonism) and the substituted amphetamine 3,4-methylenedioxymethamphetamine (MDMA). In this chapter, the evidence regarding disorders and other adverse effects attributable to these drugs, including acute toxicity, abuse potential, persistent perceptual effects (Hallucinogen Persisting Perception Disorder), psychosis, neurotoxicity, and more, are explored.