Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.

A series of N,N-dimethylaminoisotryptamine (isoDMT) analogues were synthesized and tested to identify which structural features promote psychoplastogenic activity—the ability to promote neural plasticity. Through structure-activity relationship studies, several analogues were found to induce neurite growth in cortical neurons, with some showing potency comparable to or greater than known psychoplastogens. The findings suggest that specific modifications to the isoDMT scaffold can enhance neuroplasticity-promoting effects, providing a basis for developing novel compounds that may have therapeutic potential for neuropsychiatric disorders.

Study at a glance

Abstract

Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies.