Cannabis--psychosis pathway independent of other types of psychopathology.
Robert F Ferdinand, Jan Van der Ende, Ilja Bongers, Jean-Paul Selten, Anja Huizink, Frank C Verhulst
Schizophrenia research November 15, 2005 DOI: 10.1016/j.schres.2005.07.027 via PubMed
Summary
AI-generated from the abstractCannabis use is specifically linked to later psychotic symptoms, independent of earlier psychopathology. A 14-year follow-up of 1,580 Dutch children initially aged 4 to 16 found that the association between cannabis use and psychotic symptoms remained after accounting for prior behavioral and emotional problems. The study used survival analyses and suggests cannabis use is a specific risk factor for future psychotic symptoms, not merely a consequence of prior mental health issues. This supports prevention efforts targeting cannabis use to potentially reduce psychotic symptoms in vulnerable individuals.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 1,580 |
| Population | Dutch general population children initially aged 4 to 16 |
| Duration | 14-year follow-up |
| Key finding | Cannabis use is specifically associated with psychotic symptoms independently of prior psychopathology. |
Abstract
To investigate if associations between cannabis use and psychotic symptoms occur independently, or occur as a consequence of previous-other types of-psychopathology. A 14-year follow-up study of 1580 initially 4- to 16-year-olds who were drawn randomly from the Dutch general population was conducted. At initial assessment, psychopathology was assessed with the Child Behavior Checklist. Across the 14-year follow-up period, cannabis use and psychotic symptoms were assessed with the Composite International Diagnostic Interview (CIDI). Because cannabis use is generally condoned in The Netherlands, false-negative reports of cannabis use may occur less frequently than in countries with stricter drug policies, which supports the value of the present study. Survival analyses indicated that the association between cannabis use and psychotic symptoms occurred independently of initial CBCL scores. The link between cannabis use and psychotic symptoms is specific, and does not depend on the earlier presence of other types of psychopathology. This indicates that research aimed at unraveling mechanisms that are responsible for this specific association is useful. Further, given the fact that cannabis use seemed to be a specific risk factor for future psychotic symptoms, prevention aimed against cannabis use may prohibit the onset of psychotic symptoms in vulnerable individuals.