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Cannabinoids

Linda A. Parker

February 17, 2026 DOI: 10.7551/mitpress/15756.001.0001

Summary

AI-generated from the abstract

Neuroscientist Linda Parker explains the discovery of the brain's own cannabinoid system, called endocannabinoids, and describes how this system functions and interacts with plant-derived cannabis. The book explores the role of the endocannabinoid system in regulating emotion, anxiety, depression, psychosis, learning, memory, feeding, nausea, pain, epilepsy, neurological disorders, and the brain's reward system. It offers a balanced presentation of scientific evidence for the medicinal use of marijuana, providing a timely intervention in debates about cannabis's medicinal value and legal status.

Study at a glance

Characteristics Theoretical or philosophical paper
Key finding The human brain has a special relationship with THC, including its own endocannabinoid system that regulates emotion, anxiety, depression, psychosis, learning, memory, feeding, nausea, pain, epilepsy, and neurological disorders.

Abstract

The mysteries of the brain’s own cannabinoid system exposed and explained. Though cannabis has been used, for pain or pleasure, for over 4000 years, only lately have we learned, first, what makes it work and, more recently, how. Unraveling the mystery of the human brain’s special relationship with a psychoactive chemical derived from a plant—tetrahydrocannabinol, or THC, specifically—neuroscientist Linda Parker recounts the discovery of the brain’s own THC, called endocannabinoids, and describes the remarkable brain chemical system this discovery revealed. In expert yet accessible terms, Cannabinoids explains what we know about this system, how it functions, and how it interacts with the plant materials in cannabis. Parker explores the role of the endocannabinoid system in regulating emotion, anxiety, depression, psychosis, learning, memory, feeding, nausea, pain, epilepsy, and neurological disorders—as well as, naturally, the brain’s reward system. Examining the link between anecdotal reports and the current scientific literature, the book offers a balanced presentation of the scientific evidence for the medicinal use of marijuana, providing a timely intervention in ongoing debates about cannabis’s medicinal value and its legal status.

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