Delayed changes in neural visinin-like calcium-binding protein gene expression caused by acute phencyclidine administration.
Y Kajimoto, O Shirakawa, T Kuno, N Nishino, H Nakai
Journal of neural transmission. General section January 1, 1995 DOI: 10.1007/bf01276463 via PubMed
Summary
AI-generated from the abstractIn rats, the drug phencyclidine (PCP), which produces a schizophrenia-like state, reduced the expression of a calcium-binding protein called NVP-1 in the nucleus accumbens by 42% after 24 hours. This finding suggests that changes in calcium-binding proteins may contribute to the brain pathology underlying PCP-induced psychosis and possibly schizophrenia.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Phencyclidine (PCP) |
| Duration | 24 hours |
| Key finding | PCP reduced NVP-1 mRNA levels in the nucleus accumbens by 42% after 24 hours. |
Abstract
Phencyclidine (PCP) induces a psychotomimetic state that closely resembles schizophrenia, and PCP-treated animals can serve as a model for schizophrenia. The effects of PCP on the gene expression of NVP-1, a novel Ca(2+)-binding protein, were studied in rats. After 24 hours, the NVP-1 mRNA level in the nucleus accumbens showed a significant decrease of 42%. This result suggests that alterations in Ca(2+)-binding protein may be involved in the pathology of PCP-induced psychosis and, presumably, schizophrenia.