Reply to Gattuso et al.: "Comments on 'Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming' by Brownstien et al. (2024)".

This reply addresses comments by Gattuso et al. on a previous study that reported long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in a rodent model of OCD-like excessive self-grooming. The authors defend their original findings and respond to methodological critiques, arguing that the experimental design, including the use of SAPAP3 knockout mice, is appropriate and that the observed reductions in compulsive grooming are robust. They clarify that the study was not designed to isolate specific mechanisms but to demonstrate behavioral efficacy, and they emphasize that the long-term benefits of psilocybin in this model are reproducible and statistically significant.

Study at a glance

Abstract

Reply to Gattuso et al.: "Comments on 'Striking long-term beneficial effects of single-dose psilocybin and psychedelic mushroom extract in the SAPAP3 rodent model of OCD-like excessive self-grooming' by Brownstien et al. (2024)".