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Limitations of psychedelic research in animals warrants acknowledgement

Emily Trunnell, Donya Mand

DOI: 10.22541/au.172900389.94347413/v1

Summary

AI-generated from the abstract

A commentary on a study that used animal tissues and behavioral tests to investigate psychedelic compounds for human mental health argues that the research requires more context about the limitations of those behavioral tests, whether potential benefits justify the harms to animals, and whether the study can translate to humans given it lacked human specimens or data.

Study at a glance

Characteristics Commentary
Key finding The commentary argues that the animal study on psychedelic compounds needs additional context regarding test limitations, ethical considerations, and translational capacity.

Abstract

In a recent publication in British Journal of Pharmacology, Rakoczy, et al. describe the use of animal tissues and behavioral tests to study the potential of psychedelic compounds to benefit human mental health. However, the research warrants additional context regarding the limitations of these behavioral tests, whether the proposed benefits outweigh the harms experienced by the animals used, and whether this study has translational capacity considering its lack of human specimens and data.

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