Flicker light stimulation induces thalamocortical hyperconnectivity with LGN and higher-order thalamic nuclei.
Ioanna A Amaya, Marianna E Schmidt, Marie T Bartossek, Johanna Kemmerer, Evgeniya Kirilina, Till Nierhaus, Timo T Schmidt
Imaging neuroscience (Cambridge, Mass.) January 1, 2023 DOI: 10.1162/imag_a_00033 via PubMed
Summary
AI-generated from the abstractFlicker light stimulation (FLS) induces hyperconnectivity between the lateral geniculate nucleus (LGN) and early visual areas, as well as proximal upstream areas of the ventral visual stream (e.g., hV4, VO1). An exploratory analysis indicates that higher-order thalamic nuclei, such as the anterior and mediodorsal nuclei, are strongly affected by FLS, with connectivity changes to upstream cortical visual areas directly reflecting a frequency-dependent increase in experienced visual phenomena. These findings help identify specific thalamocortical interactions involved in the emergence of visual hallucinations.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Healthy participants |
| Intervention | Flicker light stimulation |
| Topics | Altered states of consciousness |
| Keywords | Flicker light stimulation Functional connectivity Thalamic nuclei Thalamocortical connectivity Visual hallucinations |
| Key finding | FLS induces thalamocortical hyperconnectivity between LGN, early visual areas, and proximal upstream ventral visual stream areas, with higher-order thalamic nuclei showing frequency-dependent connectivity changes that reflect increases in visual phenomena. |
Abstract
The thalamus is primarily known as a relay for sensory information; however, it also critically contributes to higher-order cortical processing and coordination. Thalamocortical hyperconnectivity is associated with hallucinatory phenomena that occur in various psychopathologies (e.g., psychosis, migraine aura) and altered states of consciousness (ASC; e.g., induced by psychedelic drugs). However, the exact functional contribution of thalamocortical hyperconnectivity in forming hallucinatory experiences is unclear. Flicker light stimulation (FLS) can be used as an experimental tool to induce transient visual hallucinatory phenomena in healthy participants. Here, we use FLS in combination with fMRI to test how FLS modulates thalamocortical connectivity between specific thalamic nuclei and visual areas. We show that FLS induces thalamocortical hyperconnectivity between lateral geniculate nucleus (LGN), early visual areas, and proximal upstream areas of the ventral visual stream (e.g., hV4, VO1). Further, an exploratory analysis indicates specific higher-order thalamic nuclei, such as anterior and mediodorsal nuclei, to be strongly affected by FLS. Here, the connectivity changes to upstream cortical visual areas directly reflect a frequency-dependent increase in experienced visual phenomena. Together, these findings contribute to the identification of specific thalamocortical interactions in the emergence of visual hallucinations.