Psychedelic Therapy: A Primer for Primary Care Clinicians-The Strengths, Weaknesses, Opportunities, and Threats of Psychedelic Therapeutics.
Owen S Muir, Kenneth Shinozuka, Bryce D Beutler, Alejandro Arenas, Kirsten Cherian, Viviana D Evans, Chelsey Fasano, Burton J Tabaac
American journal of therapeutics DOI: 10.1097/MJT.0000000000001720 via PubMed
Summary
AI-generated from the abstractThis article reviews seven psychedelic compounds and their potential roles in medicine, using a SWOT (strengths, weaknesses, opportunities, threats) format to assess how they fit into the broader healthcare landscape. Historically, psychiatric conditions have been treated with small-molecule drugs that have limited effectiveness and many side effects. Psychedelic medicines may offer more potent and faster-acting treatments. However, the field is emerging: only esketamine is FDA-approved for depression, and the other compounds remain investigational, making the discussion prospective and imaginative.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Keywords | Psychedelics Mental health treatment Psychiatric medicine Drug research Therapeutic compounds |
| Citations | 5 |
| Key finding | Psychedelic compounds may offer more potent and rapidly acting treatments for psychiatric conditions compared to traditional small-molecule drugs, but only esketamine is currently FDA-approved for depression. |
Abstract
The reviews in this special edition have presented a primer on the state of the literature for 7 different psychedelic compounds and their plausible roles in medicine. In a common format underscoring strengths, weakness, opportunities, and threats (SWOT), this article addresses how psychedelic compounds fit into the broader health care landscape for indicated conditions. Historically, psychiatric pathologies have been treated with small-molecule compounds that have limited effect sizes and carry a variety of adverse effect profiles. Psychedelic medicines offer the opportunity to provide more potent and rapidly acting treatments. It is crucial to note that this is an emerging field of medicine, and only one of these compounds (esketamine) is currently Food and Drug Administration-approved for depression. The other compounds discussed are investigational, and this discussion is both imaginative and prospective in nature.