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Novel 5,6-Bicyclic Compounds as 5-HT2A Receptor Agonists for Treating Depression, Anxiety, Substance Abuse, and Headaches

Ram W. Sabnis, Anika R. Sabnis

ACS Medicinal Chemistry Letters June 3, 2026 DOI: 10.1021/acsmedchemlett.6c00270 via OpenAlex

Summary

AI-generated from the abstract

This patent describes novel 5,6-bicyclic compounds that act as agonists of the 5-HT2A receptor. These compounds are intended for use in pharmaceutical compositions to treat conditions such as depression, anxiety, substance abuse, and headaches. The document also outlines processes for synthesizing these compounds. No experimental data, results, or clinical findings are presented.

Study at a glance

Characteristics Peer reviewed
Keywords Headaches Agonist Receptor Drug Migraine

Abstract

Provided herein are novel 5,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

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